General Information

  • ID:  hor004552
  • Uniprot ID:  C0HKT6
  • Protein name:  SAIDRSMIRF-amide
  • Gene name:  NA
  • Organism:  Agrotis ipsilon (Black cutworm moth)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  RFamide 1: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level). Expression in AL detected in most animals, in CC, CA and in GNG in some animals (at protein level). RFamide precursor-rel
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Agrotis (genus), Noctuini (tribe), Noctuinae (subfamily), Noctuidae (family), Noctuoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SAIDRSMIRF
  • Length:  10
  • Propeptide:  MSCSRTVALLAALWLVVGATSSPVRRSPDLEARRRSAIDRSMIRFGRSYPPEPSAADIREAFERPTRRGNSFLRFGRSQPLTLSTDDLVSLLRAYEEDYDTPMTKKSASFVRFGRDPNFIRLGRSADDDKSAFEQNSELVVSGYPQRKSRARDHFIRLGRDSEEVNENEFEETEESRRKRSADSCHDCQS
  • Signal peptide:  MSCSRTVALLAALWLVVGATS
  • Modification:  T10 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  In insects, FMRFamide and related peptides have modulatory actions at skeletal neuromuscular junctions, and peptides that are immunologically related to FMRFamide are released into the circulation from neurohemal organs.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-C0HKT6-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004552_AF2.pdbhor004552_ESM.pdb

Physical Information

Mass: 135611 Formula: C51H86N16O15S
Absent amino acids: CEGHKLNPQTVWY Common amino acids: IRS
pI: 10.4 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 14 Boman Index: -2838
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 88
Instability Index: 4540 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  29466015
  • Title:  Mating-Induced Differential Peptidomics of Neuropeptides and Protein Hormones in Agrotis Ipsilon Moths